SAP30 Polyclonal Antibody, 20ul 3D Culture The protein encoded by MAP3K7

The protein encoded by MAP3K7 (mitogen-activated protein kinase kinase kinase 7) is a member of the serine/threonine protein kinase family

It has a domain organization reminiscent of spliceosomal proteins

This gene encodes a preproprotein that is proteolytically processed to generate multiple biologically active peptides

The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16

Mutations in this gene cause Gitelman syndrome| a disease similar to Bartter's syndrome| that is characterized by hypokalemic alkalosis combined with hypomagnesemia| low urinary calcium| and increased renin activity associated with normal blood pressure

SAP30 Polyclonal Antibody, 20ul 3D Culture The protein encoded by MAP3K7Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A