MARCH2 Polyclonal Antibody, 100ul Recombinant Protein homologs to the yeast Sir2

homologs to the yeast Sir2 protein

Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR)

Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity

Easy to switch between manual aspiration and continuous aspiration mode

MARCH2 Polyclonal Antibody, 100ul Recombinant Protein homologs to the yeast Sir2MARCH2 (membrane associated ring CH type finger 2) is a member of the MARCH family of membrane bound E3 ubiquitin ligases. MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome to trans Golgi network (TGN) trafficking.