Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 50ul Organelle Studies TP53 encodes a tumor suppressor

TP53 encodes a tumor suppressor protein containing transcriptional activation

It is heterogeneously expressed in the brain

ALK encodes a receptor tyrosine kinase

It contains a 5' CpG island that may be a frequent target of hypermethylation| and it may undergo hypermethylation-based silencing in some bladder cancers

Cytoplasmic ribosomes

Tuberin/TSC2(Phospho-Ser1387) Rabbit Polyclonal Antibody, 50ul Organelle Studies TP53 encodes a tumor suppressorMutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.