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Phospho-Brk (Y447) Polyclonal Antibody, 50ul miRNA / siRNA Synthesis and tumor growth and metastasis

SKU: 99930384352

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PLN162.00 PLN193.00

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Phospho-Brk (Y447) Polyclonal Antibody, 50ul miRNA / siRNA Synthesis and tumor growth and metastasisThe protein encoded by PTK6 (protein tyrosine kinase 6) is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of PTK6 has been detected at low levels in some breast tumors but not in normal breast tissue. The

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Description

and tumor growth and metastasis

The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis

It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine

which interacts with the sliding DNA clamp protein PCNA

this interaction leads to a cooperativity between the two proteins in DNA binding

Phospho-Brk (Y447) Polyclonal Antibody, 50ul miRNA / siRNA Synthesis and tumor growth and metastasisThe protein encoded by PTK6 (protein tyrosine kinase 6) is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of PTK6 in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of PTK6 has been detected at low levels in some breast tumors but not in normal breast tissue. The

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