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Both medications affect different body systems and require careful monitoring when used concurrently

A reasonable clinical approach suggests stopping semaglutide at least two months before attempting pregnancy, allowing the medication to clear your system and giving your body time to stabilize

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Those prescribed GLP-1 medications for weight management through NHS specialist services (typically individuals with BMI 35 kg/m or 30 kg/m with comorbidities, according to NICE criteria) may target a larger calorie deficit than those using these medications primarily for glycaemic control with modest weight management

Note: Originally published in October 2018, this article has been revised and updated for accuracy and thoroughness.