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DIET REVIEW SCORECARD Overall score: 4.46 Weight loss: 4.5 Healthy eating: 5 Sustainability: 4 Whole body health: 4.25 Nutrition quality: 5 Evidence based: 4 BOTTOM LINE: The Mayo Clinic Diet is a balanced meal plan that focuses on healthy foods and regular exercise

Importantly, the majority of sulforaphanes neuroprotective effects are mediated by NRF2, since the absence of NRF2 prevents sulforaphanes effects (Innamorato et al., 2008