can you use glp 1 and dpp4 together GLP-1 receptor agonist versus DPP-4 inhibitor kidney and cardiovascular outcomes in clinical practice in type-2 diabetes Mechanism of Action of GLP-1RAs

Name: can you use glp 1 and dpp4 together GLP-1 receptor agonist versus DPP-4 inhibitor kidney and cardiovascular outcomes in clinical practice in type-2 diabetes Mechanism of Action of GLP-1RAs
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Mechanism of Action of GLP 1RAs and DPP 4 inhibitors. DPP 4 inhibitors Download Scientific Diagram Linagliptin:The Mechanism: How Does It Work? DPP 4 inhibitors are based on incretin physiology. After a meal, the gut releases GLP 1, which enhances insulin secretion under hyperglycemic conditions and suppresses glucagon. However, GLP 1 Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus Nature Reviews Endocrinology Can DPP 4 (Dipeptidyl Peptidase 4) inhibitors be used with GLP 1 (Glucagon Like Peptide 1) receptor agonists in type 2 diabetes treatment? DPP 4 inhibitors and GLP 1RAs: cardiovascular safety and benefits Military Medical Research Springer Nature Link

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The study focused on two genetic variants that affect the enzyme peptidyl-glycine alpha-amidating monooxygenase (PAM)

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Safety considerations include medical clearance before starting any GLP-1 therapy, regular provider monitoring for gastrointestinal side effects and metabolic changes, and screening for contraindications such as personal or family history of medullary thyroid cancer or MEN2 syndrome