SBE13 onazole D8 Smiles: [2H]C1=C(C2=C(/C=C/[C@@H](O)C[C@@H](O)CC(O)=O)C(=NC3=CC=CC=C32)C2CC2)C([2H])=C([2H])C(F)=C1[2H]

Smiles: [2H]C1=C(C2=C(/C=C/[C@@H](O)C[C@@H](O)CC(O)=O)C(=NC3=CC=CC=C32)C2CC2)C([2H])=C([2H])C(F)=C1[2H]

PubMed Central PMCID: PMC5673922

TAS4464 is a potent and highly selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0

Smiles: CC1C=CC(=CC=1)NC1=CC(=O)C2SC(C)=NC=2C1=O

Chemical Name: 3-phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol

SBE13 onazole D8 Smiles: [2H]C1=C(C2=C(/C=C/[C@@H](O)C[C@@H](O)CC(O)=O)C(=NC3=CC=CC=C32)C2CC2)C([2H])=C([2H])C(F)=C1[2H]SBE13 is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 poorly inhibits Plk2 (IC50>66 M) or Plk3 (IC50=875 nM). Product information CAS Number: 775294 82 1 Molecular Weight: 442. 94 Formula: C24H27ClN2O4 Synonym: SBE 13 Chemical Name: ({4 [(6 chloropyridin 3 yl)methoxy] 3 methoxyphenyl}methyl)[2 (3,4 dimethoxyphenyl)ethyl]amine Smiles: COC1=CC=C(CCNCC2C=C(OC)C(=CC=2)OCC2=CN=C(Cl)C=C2)C=C1OC InChiKey: XNPRQBVQOJZMMA UHFFFAOYSA N