GK921 Catalog No.:M8587-2 PubMed PMID: 29047383

PubMed PMID: 29047383

Smiles: CCC1=NN(CCO)C(CC)=C1OC1C=C(C=C(C=1)C#N)C#N

AB928 shows rescue of these gene expression changes

Molecular Weight: 460

Chemical Name: 2-chloro-6-[(2R)-2-hydroxy-3-{[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino}propoxy]benzonitrile

GK921 Catalog No.:M8587-2 PubMed PMID: 29047383GK921 is a transglutaminase 2 (TGase 2) inhibitor. GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0. 905 M). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI 1 preclinical xenograft tumor models. TGase 2 inhibitor GK921 abrogates RCC growth in xenograft tumor models, suggesting the possibility of a new therapeutic approach to RCC. Product information CAS Number: