K-7174 Catalog No.:M8324-2 PubMed PMID: 21933026
DKK107.10
DKK146.10
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K-7174 Catalog No.:M8324-2 PubMed PMID: 21933026K 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product
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