AZD-5438 Size:Solid 2 mg FASN-IN-4 tosylate is a potent

FASN-IN-4 tosylate is a potent inhibitor of fatty acid synthase (FASN) extracted from patent WO 2012064642 A1

the major inhibitory neurotransmitter in the central nervous system by blocking the GABA transporter and hence is classified as a GABA reuptake inhibitor

selective and bioavailable CK2 (Casein Kinase 2) Inhibitor with IC50 of 1 nM

Losartan D4 Carboxylic Acid (E-3174 D4) is the deuterium labeled Losartan(EXP-3174)

OVCAR8 (ovary)

AZD-5438 Size:Solid 2 mg FASN-IN-4 tosylate is a potentAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.