Erastin syl-L-homocysteine (SAH) Chemical Name: 6-[(2S

Chemical Name: 6-[(2S

Reduction in prostaglandin E2 synthesis also led to reduced level of VEGF in plasma

In nice transplanted with osteosarcoma (OS) cells

Formula: C28H44O

and metabolism of 10074-G5

Erastin syl-L-homocysteine (SAH) Chemical Name: 6-[(2SErastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i. e. HRAS, KRAS). Erastin produces non apoptotic tumor cell death by altering mitochondrial voltage dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death. Erastin blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized