Exatecan Mesylate - CAS# 169869-90-3 noprol whereas the IC50s of Y-27632
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Exatecan Mesylate - CAS# 169869-90-3 noprol whereas the IC50s of Y-27632Exatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater
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