K-7174 dihydrochloride estin (ML246) [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCC1=CC=CS1)[C@@H]1CC2=CC=CC(O)=C2CC1

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCC1=CC=CS1)[C@@H]1CC2=CC=CC(O)=C2CC1

21-dimethoxy-6

A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats

Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-β signalling in 7

CFTR Inhibitor II inhibits SLC26A9-mediated Cl- currents

K-7174 dihydrochloride estin (ML246) [2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCC1=CC=CS1)[C@@H]1CC2=CC=CC(O)=C2CC1K 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product