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Eptapirone - CAS# 179756-58-2 size:2mg solid 21)14-5-2-4-12-9-18-10-13(16)15(12)14

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Eptapirone - CAS# 179756-58-2 size:2mg solid 21)14-5-2-4-12-9-18-10-13(16)15(12)14Eptapirone, CAS No. 179756 58 2also known as F11440 and L0068, is a potent, selective, high efficacy 5 HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5 HT1A binding sites (pKi, 8. 33) was higher than that of buspirone (pKi, 7. 50), and somewhat lower than that of flesinoxan (pKi, 8. 91). In vivo, F 11440 was 4 to 20 fold more potent than flesinoxan, and 30 to 60 fold more potent than buspirone.

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21)14-5-2-4-12-9-18-10-13(16)15(12)14

and monkeys (3 mg/kg)

2014 Feb 5

are significantly lower than the IC50 values calculated for cells cultured in the presence of PAI-039 under attached condition

Phytochem Anal

Eptapirone - CAS# 179756-58-2 size:2mg solid 21)14-5-2-4-12-9-18-10-13(16)15(12)14Eptapirone, CAS No. 179756 58 2also known as F11440 and L0068, is a potent, selective, high efficacy 5 HT1A receptor agonist with marked anxiolytic and antidepressant potential. The affinity of F 11440 for 5 HT1A binding sites (pKi, 8. 33) was higher than that of buspirone (pKi, 7. 50), and somewhat lower than that of flesinoxan (pKi, 8. 91). In vivo, F 11440 was 4 to 20 fold more potent than flesinoxan, and 30 to 60 fold more potent than buspirone.

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