Silvestrol (aglycone) SMI-4 is a novel potent and

is a novel potent and selective PKCθ inhibitor

Hep 3B cells) treatment increases CYP7A1 mRNA expression and the expression of the proliferative marker EGR1 is inhibited

Formula: C18H17FN4O

Schnell MJ

6(27):24061-74

Silvestrol (aglycone) SMI-4 is a novel potent andSilvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc LUC and tub LUC luciferase reporter protein translation, respectively. Anti cancer activity. Product information CAS Number: 960365 65 5 Molecular Weight: 478. 49 Formula: C27H26O8 Chemical Name: methyl (2S,3R,4R,5S,6R) 2,3,10 trihydroxy 12 methoxy 6 (4 methoxyphenyl) 5 phenyl 7 oxatricyclo[6. 4. 0. 0,]dodeca