AZD1981 hlorophen InChiKey: ZVDSAIOSGOWYAW-CKLTXHEASA-N

InChiKey: ZVDSAIOSGOWYAW-CKLTXHEASA-N

IC50 value: Target: cathepsin K The cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005

26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27

sometimes abbreviated to neohesperidin DC or simply NHDC

02 mM) Ethanol 2 mg/mL (7

AZD1981 hlorophen InChiKey: ZVDSAIOSGOWYAW-CKLTXHEASA-NAZD1981is an orally available selective CRTH or DP2 antagonist currently in clinical development for asthma. AZD1981 blocks functional responses in eosinophils, Th2 cells and basophils. AZD1981 displaced radio labelled PGD2 from human recombinant DP2 with high potency (pIC50 = 8. 4). Binding was reversible, non competitive and highly selective against a panel of more than 340 other enzymes and receptors, including DP1 (>1000 fold selective). AZD1981