CCT128930 - CAS# 885499-61-6 iapine D8 fumarate The pimecrolimus-macrophilin complex prevents the

The pimecrolimus-macrophilin complex prevents the dephosphorylation of the cytoplasmic component of the nuclear factor of activated T cells by inhibiting the action of calcineurin

It induces allosteric activation of AMPK and inhibition of dephosphorylation of AMPK on Thr-172

SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease induced by amyloid β and excitatory amino acids

Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling

2-/m111/s1

CCT128930 - CAS# 885499-61-6 iapine D8 fumarate The pimecrolimus-macrophilin complex prevents theCCT128930 is a novel ATP competitive AKT inhibitor discovered using fragment and structure based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA, achieved by targeting a single amino acid difference. CCT128930 exhibited marked antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition.