SB 242235 - CAS# 193746-75-7 iglustat Hydrochloride 73(11):3336-3346

73(11):3336-3346

Grzebieniak Z

InChiKey: ITVGXXMINPYUHD-CUVHLRMHSA-N

Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with involvement of AKT and FAK dephosphorylation

CAS Number: 29342-05-0

SB 242235 - CAS# 193746-75-7 iglustat Hydrochloride 73(11):3336-3346SB 242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine mediated diseases such as autoimmune or inflammatory diseases. SB 242235 demonstrates generally favourable pharmacokinetic properties. Systemic plasma clearance was high in rat, but in the non rodent species SB 242235 demonstrated low to moderate clearance with plasma half lives > 4h. Oral bioavailability in each preclinical species was high. In