MLN0905 - CAS# 1228960-69-7 medil Hydrochloride 5(7):1774-82

5(7):1774-82

Chemical Name: N-[(2S

Chemical Name: 12-chloro-4-[(2S)-pyrrolidin-2-yl]-8-oxa-3

¹⁷]nonadecane-5

extending from maintenance of pancreatic β cell survival and proliferation to the induction of apoptosis in cancer cells

MLN0905 - CAS# 1228960-69-7 medil Hydrochloride 5(7):1774-82MLN0905 is a potent, selective small molecule PLK1 inhibitor. MLN0905 inhibits cell proliferation in a broad range of human tumor cells including DLBCL cell lines. PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models. These data strongly suggest evaluating PLK1 inhibitors as DLBCL anticancer agents in the clinic. (source: Mol Cancer Ther; 11(9); 2045 53.) Product information CAS Number: