Coluracetam lunarizine dihydrochloride 19(1):291-300

19(1):291-300

SGK3-PROTAC1 suppresses proliferation of ZR-75-1 and CAMA-1 cancer cell lines treated with a PI3K inhibitor more effectively than could be achieved by a conventional SGK isoform inhibitor

EC(50) = 490 nmol/L)

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader

In agreement with the in vitro study

Coluracetam lunarizine dihydrochloride 19(1):291-300Coluracetam, also known as BCI 540; MKC 231, is a AMPA receptor agonist potentially for the treatment of major depression and anxiety. MKC 231 antagonizes phencyclidine induced behavioral deficits and reduction in septal cholinergic neurons in rats. MKC 231 ameliorates working memory deficits and decreased hippocampal acetylcholine induced by ethylcholine aziridinium ion in mice. Product information CAS Number: 135463 81 9 Molecular Weight: 341. 40