Metarrestin (ML246) Size:100 mg solid 36(9):1348-1357

36(9):1348-1357

TH-302 exhibits potent cytotoxicity to both human and murine MM cells with hypoxic selectivity and dose dependency

Smiles: CN1C(=O)N(C2=C1C=NC1=CC=C(C=C12)C1=CN=C(C=C1)OC)C1=CC=C(C=C1)N1CCNC(C1)C(F)(F)F

2817-2822 (2004)

CAS Number: 2139348-63-1

Metarrestin (ML246) Size:100 mg solid 36(9):1348-1357Metarrestin (ML246) is an orally active and specific perinucleolar compartment (PNC) inhibitor that disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription. Metarrestin blocks metastatic development and extends survival in mouse cancer models. Product information CAS Number: 1443414 10 5 Molecular Weight: 474. 60 Formula: C31H30N4O Chemical Name: Trans 4 (7 benzyl 4 imino 5,6 diphenyl 4,7 dihydro 3H pyrrolo[2,3 d]pyrimidin 3