SKLB1002 Catalog No.:M9542-2 Smiles: CC(C)C[C@H](NC=O)C(=O)O[C@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)CCCCCCCCCCC
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SKLB1002 Catalog No.:M9542-2 Smiles: CC(C)C[C@H](NC=O)C(=O)O[C@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)CCCCCCCCCCCSKLB1002 is a new potent VEGFR2 inhibitor, which could significantly inhibit HUVEC proliferation, migration, invasion, and tube formation. Western blot analysis was conducted, which indicated that SKLB1002 inhibited VEGF induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase, focal adhesion kinase, and Src. In vivo zebrafish model experiments showed that SKLB1002 remarkably blocked
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