TAK-715 Catalog No.:M10952-2 47(8):2438-41

47(8):2438-41

Endometriosis is an estrogen (ER)-dependent gynecological disease caused by the growth of endometrial tissue at extrauterine sites

The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer

121(4):627-631

and caspase-9 and poly (ADP) ribosome polymerase

TAK-715 Catalog No.:M10952-2 47(8):2438-41TAK 715 is a potent p38 MAPK inhibitor. which displays potent inhibitory activity (inhibition of p38alpha, IC50 = 7. 1 nM; LPS stimulated release of TNF alpha from THP 1, IC50 = 48 nM; LPS induced TNF alpha production in mice, 87. 6% inhibition at 10 mg kg, po) and no inhibitory activity for major CYPs, including CYP3A4. TAK 715 was selected as a clinical candidate and is now under clinical investigation for the treatment of RA. Product information