Talnetant Hydrochloride Size:Solid 2 mg Takinib inhibits phosphorylation of IKK
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Talnetant Hydrochloride Size:Solid 2 mg Takinib inhibits phosphorylation of IKKTalnetant (SB 223412) is a potent and selective NK3 receptor antagonist (ki=1. 4 nM, hNK 3 CHO); 100 fold selective for the hNK 3 versus hNK 2 receptor, with no affinity for the hNK 1 at concentrations up to 100 uM. IC50 Value: 1. 4 nM (hNK 3 CHO binding Ki) Target: NK3 receptorin vitro: In vitro studies demonstrated that 53 is a potent functional antagonist of the hNK 3 receptor (reversal of senktide induced contractions in rabbit isolated iris
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