TMPA-AMPK Activator - CAS# 1258275-73-8 60435 Drug Metab Dispos
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TMPA-AMPK Activator - CAS# 1258275-73-8 60435 Drug Metab DisposTMPA, CAS No. 1258275 73 8, is a novel small molecule that binds to orphan Nuclear Receptor Nur77 with high affinity (Kd = 1. 45 0. 35 M), and interferes with the Nur77 LKB1 interaction. TMPAs binding to Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPK. TMPA treatment can effectively reduce blood glucose and alleviate insulin resistance in type II db db and high fat diet and streptozotocin induced diabetic mice
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