Setiptiline Size:Solid 10 mg Solubility: DMSO: 91 mg/mL(201

Solubility: DMSO: 91 mg/mL(201

is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

Garsetti D

CS-0106354

Setiptiline Size:Solid 10 mg Solubility: DMSO: 91 mg/mL(201Setiptiline, also known as MO 8282 and teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida. Setiptiline acts as a norepinephrine reuptake inhibitor,[3] 2 adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5 HT2A, 5 HT2C, and or 5 HT3 subtypes, as well as an H1 receptor