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doi: 10.1126/science.aal3662

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Consequently, its known salutary effect on gastrointestinal lesions, its effect on chronic inflammation lesions such as adjuvant arthritis and its effect as a non-steroidal anti-inflammatory agent in NSAlAs-induced gastrointestinal lesions were simultaneously studied in rats

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Long-acting GLP-1R agonists including Semaglutide may produce biased agonism and preferential activation of Gs versus Gq/11 versus beta-arrestin signalling pathways , relative to native GLP-1, with the albumin-bound fatty acid conjugate form potentially modifying the receptor contact geometry in ways that favour specific downstream pathway engagement