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INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg A-803467 affects multiple biophysical characteristics

INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg A-803467 affects multiple biophysical characteristics

Name: INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg A-803467 affects multiple biophysical characteristics
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SKU: 34868380424
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INCB3344 - CAS# 1262238-11-8 Size:Solid 2 mg A-803467 affects multiple biophysical characteristicsINCB3344 is a potent and selective antagonist of CCR2 receptor with IC(50) values of 5. 1 nM (hCCR2) and 9. 5 nM (mCCR2) in binding antagonism and 3. 8 nM (hCCR2) and 7. 8 nM (mCCR2) in antagonism of chemotaxis activity. INCB3344 exhibited >100 fold selectivity over other homologous chemokine receptors, a free fraction of 24% in human serum and 15% in mouse serum, and an oral bioavailability of 47% in mice, suitable as a tool compound for target

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Description

A-803467 affects multiple biophysical characteristics of the canonical cardiac Nav1

Inflammation

is a selective inhibitor of transforming growth factor-β type I receptor (ALK5

Schneider R

778270-11-4

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