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For instance, studies in germ-free or antibiotic-treated mouse and rhesus monkey models have demonstrated reduced levels of BBB tight junction proteins (e.g., claudin-5, occludin) and increased BBB permeability

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Am J Med Genet 49:8387

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[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Kang Y.P., Mockabee-Macias A., Jiang C., Falzone A., Prieto-Farigua N., Stone E., Harris I.S., DeNicola G.M