S0859 - CAS# 1019331-10-2 AD(OMe)-FMK Ciclopirox is a broad spectrum

Ciclopirox is a broad spectrum antimycotic agent with some antibacterial activity

25 μM for MDA-468

Chemical Name: 4-{6-[6-(4-methylpiperazin-1-yl)-1H-1

InChi: InChI=1S/C6H10N4

1-1 µM final concentration in vitro and in cellular assays

S0859 - CAS# 1019331-10-2 AD(OMe)-FMK Ciclopirox is a broad spectrumS0859 is a selective, high affinity generic NBC inhibitor, potentially important for probing the transporter's functional role in heart and other tissues. S0859 reversibly inhibited NBC mediated pH(i) recovery (K (i)=1. 7 microM, full inhibition at approximately 30 microM). In HEPES buffered superfusates, NHE mediated pH(i) recovery was unaffected by 30 microM S0859. With CO(2) HCO(3) ( ) buffer, pH(i) recovery from intracellular alkalosis (mediated