CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 Molecular Weight: 232

Molecular Weight: 232

392(2):77-80

A very useful small molecule collection to improve CRISPR editing efficacy

CXCL1 concentration in the serum peaking at 3 h after the injection

ADX47273 had no effect on single-session and multi-session extinction

CB-5083 - p97 AAA ATPase Inhibitor. CAS# 1542705-92-9 60077 Molecular Weight: 232CB 5083, CAS No. 1542705 92 9, is a novel first in class, potent orally bio available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti tumor activity in solid and hematological models . CB 5083 causes rapid and sustained accumulation of poly ubiquitin in tumor xenografts after a single administration. CB 5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB 5083 appears to