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Ethical approval The study was conducted according to the guidelines in the Declaration of Helsinki, and the Regional Ethics Committee for Medical Research in South East Norway both studies

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Although the safety of topical and oral GSH seems to be good, their efficacy (especially long-term) remains questionable

TH and ES: manuscript preparation, reviewing the manuscript and project administration

166 Moreover, oridonin, a tetracyclic diterpenoid extracted from Rabdosia labtea , induced markers associated with apoptosis in gemcitabine-resistant PANC-1 pancreatic cancer cells, while concurrently inhibiting the expression of GSTP1