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Nrf2 can bind to AREs on PINK1 promoter, and then upregulate PINK1 expression and promote mitophagy (Murata et al., 2015

Chest 134(6), 2008

In addition, studies of the Native American Pima people have shown that those residing in Arizona have highest prevalence of obesity vs those living in a traditional lifestyle in remote area of Mexico(BMI was 24.9 vs 33.4)