Elesclomol ariin also known as SM04690

also known as SM04690

Chemical Name: 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3

but promotes Akt/PKB down-regulation and GSK3 activation

Smiles: CC1=C2OC3=C(C=CC=C3CC(O)=O)C(=O)C2=CC=C1C

FH535 increases the radiosensitivity and reverses epithelial-to-mesenchymal transition of radioresistant esophageal cancer cell line KYSE-150R

Elesclomol ariin also known as SM04690Elesclomol, also known as STA 4783, is a HSP 90 Inhibitor, and is a small molecule bis(thio hydrazide amide) with oxidative stress induction, pro apoptotic, and potential antineoplastic activities. Elesclomol induces oxidative stress, creating high levels of reactive oxygen species (ROS), such as hydrogen peroxide, in both cancer cells and normal cells. Because tumor cells have elevated levels of ROS compared to normal cells, the increase in oxidative