OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 size:10mg solid Cancer Discov

Cancer Discov

As LSD1 plays an important role in the epigenetic control of gene expression in normal development and cancer progression

Khelwatty SA

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

CAS Number: 1542705-92-9

OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 size:10mg solid Cancer DiscovOSI 027, CAS No. 936890 98 1, is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. It shows more than 100 fold selectivity for mTOR relative to PI3K, PI3K, PI3K, and DNA PK. It inhibits phosphorylation of the mTORC1 substrates 4E BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 shows robust antitumor activity in several different human xenograft