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Methods: High dose of 5 mg/kg for 4 consecutive days subcutaneous (S.C) injection of methotrexate for induction of acute liver injury

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

[DOI] [PubMed] [Google Scholar] 105.Erickson AM, Nevarea Z, Gipp JJ, Mulcahy RT

In addition to energy production, mitochondria perform multiple other functions including Ca 2+ homeostasis [86, 87], generation of ROS [88], regulation of apoptosis [89], activation of endoplasmic reticulum-stress response [90], as well as other far-ranging sequelae of mitochondrial dysfunction [91]

Ngoi ra ni tng ng vt cn cha cht chng oxy ha coenzyme Q10 (CoQ10) v vitamin A gip bo v glutathione trc tc hi ca phn ng stress oxy ha