R-112 f Histone Demethylase KB-R7943 mesylate

KB-R7943 mesylate

Meeting: 2011 ASCO Annual Meeting

is a potent protein kinase CK2 inhibitor

TAE684 inhibits STAT3 and STAT5 phosphorylation in a dose-dependent manner in both Ba/F3 NPM-ALK and Karpas-299 cells

NC[C@H]1OB(O)C2=C1C=CC=C2OCCCO

R-112 f Histone Demethylase KB-R7943 mesylateR112 is a Syk inhibitor. R112 inhibited degranulation induced by anti IgE cross linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol L) or basophils (histamine release, EC(50) = 280 nmol L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization