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GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Formula: C30H40ClN7O3S

GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Formula: C30H40ClN7O3S

Name: GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Formula: C30H40ClN7O3S
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GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Formula: C30H40ClN7O3SGS143, CAS No. 916232 21 8, is selective TrCP1 ligase inhibitor, inhibits IB ubiquitination with IC50 ~5. 2 M without affecting proteasome activity. It blocks LPS induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen induced NFB expression, inflammation and mucus production in airways of OVA sensitized mice. Product information CAS Number: 916232 21 8 Molecular Weight: 466. 46 Formula: C28H19FN2O4 Chemical

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Description

Formula: C30H40ClN7O3S

5-2 µM final concentration in vitro and in cellular assays

Filippakopoulos

Specifically

CUDC-907 was used at 0

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