EMAL4 Rabbit Polyclonal Antibody, 100ul Endonucleases & Exonucleases Fibronectin type III domains are

Fibronectin type III domains are present in both extracellular and intracellular proteins and tandem repeats are known to contain binding sites for DNA| heparin and the cell surface

Mutations at this locus have been associated with microcephaly| seizures| and developmental delay

subunit:Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro

No complicated steps

Related pseudogenes have been defined on chromosomes 8 and 20

EMAL4 Rabbit Polyclonal Antibody, 100ul Endonucleases & Exonucleases Fibronectin type III domains areThis gene is a member of the echinoderm microtubule associated protein like family. The encoded WD repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene which generates EML4 ALK fusion transcripts is one of the primary mutations associated with non small cell lung cancer. Alternative splicing of this gene results in two transcript variants.