RN-1 - LSD1 Inhibitor. CAS# 1781835-13-9 size:10mg solid 21(7):1787-94

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RN-1 - LSD1 Inhibitor. CAS# 1781835-13-9 size:10mg solid 21(7):1787-94RN 1, CAS No. 1781835 13 9, is a potent, specific and brain penetrant Lysine Specific Demethylase 1 (LSD1) inhibitor. RN 1 inhibits LSD1 in biochemical assay with an IC50 ~70 nM, and has weaker activity against monoamine oxidase proteins MAO A and MAO B with IC50 ~0. 51 M and 2. 79 M respectively. It exhibits good brain penetration and retention following systemic administration. RN 1 can abolish long term memory formation without affecting short term

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