MAK-683 - CAS# 1951408-58-4 size:10mg solid J Dermatolog Treat

J Dermatolog Treat

DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis

Te Poele RH

The corresponding cAC10-L4-MMAF4 ADC was much less toxic

pii: S0165-0270(17)30146-2

MAK-683 - CAS# 1951408-58-4 size:10mg solid J Dermatolog TreatMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED