AR7 - RARα antagonist. CAS# 80306-38-3 302 Aticaprant (CERC-501) shows no appreciable

Aticaprant (CERC-501) shows no appreciable affinity for several non-opioid cell surface G-protein-coupled receptor targets

Formula: C27H41NO2

Consistent with the enhanced Akt phosphorylation

Chemical Name: (1r

951 are approximately 2000-fold selective for the glycine binding site relative to the glutamate recognition sites

AR7 - RARα antagonist. CAS# 80306-38-3 302 Aticaprant (CERC-501) shows no appreciableAR7, CAS No. 80306 38 3, was developed as a highly potent and selective enhancer of the chaperone mediated autophagy (CMA) through antagonizing RAR. It is a synthetic derivative of all trans retinoic acid developed through the structure based chemical design. CMA contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. A decrease in CMA activity occurs in aging