Tasisulam(LY573636) - CAS# 519055-62-0 060 CAS Number: 1260907-17-2

CAS Number: 1260907-17-2

8 mg/mL (Need ultrasonic)

PKCδ and PKCζ with IC50 of 7 nM

Sinkorova Z

The deleterious synergistic effect between ER-stress and ISRIB may be generally advantageous to kill cancer cells

Tasisulam(LY573636) - CAS# 519055-62-0 060 CAS Number: 1260907-17-2Tasisulam, also known as LY573636, CAS No. 519055 62 0, is an acyl sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.