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SGLT2 brain expression is lower compared to SGLT1, and it is localized mainly in the microvessels of the blood-brain barrier, in the amygdala, hypothalamus, periaqueductal gray, and in the dorsomedial medulla (Wiciski et al., 2020)

Semaglutide alone can promote weight loss but produces better results when combined with diet, exercise, and creating a healthy life

Wenz, T

Larger and more diverse patient cohorts are needed, lower dosages of semaglutide have to be tested, and follow-ups need to be conducted beyond 26 weeks.