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ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 60252 Molecular Weight: 302

ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 60252 Molecular Weight: 302

Name: ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 60252 Molecular Weight: 302
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ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 60252 Molecular Weight: 302ORY 1001, CAS No. 1431326 61 2, is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM. It is highly selective over related enzymes such as MAO A B. ORY 1001 affects AML stem cells, a sub population of cancer cells that has been proposed to be responsible for frequent relapses of the disease. It significantly reduces tumor cell load and increases survival time in mouse models of Acute Lymphoblastic

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Description

Molecular Weight: 302

Smiles: C/C(=N\NC(=O)C(NC(=O)C1C=CC=CC=1)C1=NNC(=O)C2=CC=CC=C21)/C1=CC(Br)=CC=C1

pAKT (S473) IC50 = 0

2008 Nov 1

CAS Number: 133053-19-7

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