Corynoxine B upitant metabolite Monohydroxy Netupitant with an extrapolated geometric mean

with an extrapolated geometric mean IC50 of approximately 20 mM resulting in a predicted selectivity index of 166

PD173074 treatment completely abolishes NIH 3T3 transformation mediated by Y373C FGFR3 but not by Ras V12

the pimecrolimusmacrophilin complex then binds to the cytosolic enzyme calcineurin phosphatase

Formula: C31H38N6O2

CAS Number: 393105-53-8

Corynoxine B upitant metabolite Monohydroxy Netupitant with an extrapolated geometric meanCorynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin 1 dependent autophagy inducer. IC50 value: Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA HMGB1 interaction . in vivo: Corynoxine B exhibited prolongation