OTSSP167 - CAS# 1431697-89-0 Catalog No.:M9991-10 Chemical Name: A name could

Chemical Name: A name could not be generated for this structure

Smiles: CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)N1C3C(=C4C(O)NC(=O)C4=C4C=3N2C2=CC=CC=C24)C2=CC=CC=C12)NC

[Epub ahead of print] PubMed PMID: 27989726

Peräniemi S

The IC50 of Halofuginone for global protein synthesis is 22

OTSSP167 - CAS# 1431697-89-0 Catalog No.:M9991-10 Chemical Name: A name couldOTSSP167, also known as OTS167, is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK expressing tumor cells. Product information CAS