CDKI-73 60295 InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7

InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7

Bornmann W

PubMed PMID: 25059319

InChi: InChI=1S/C17H20F2N4O3S/c1-27(24

SC-514 inhibits the native IKK complex or recombinant human IKK-1/IKK-2 heterodimer with IC50s of 6

CDKI-73 60295 InChi: InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7CDKI 73 is a potent CDK9 inhibitor with Ki of 4 nM. It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM). The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin. Product information CAS Number: 1421693 22 2 Molecular Weight: 394. 45 Formula: C15H15FN6O2S2 Chemical Name: 3 ({5 fluoro 4 [4 methyl 2 (methylamino) 1,3 thiazol 5 yl]pyrimidin 2 yl}amino)benzene 1 sulfonamide