Raltegravir (MK-0518) r Agonist Androgen synthesis inhibitors in the

Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer

It incorporates an E3 ligase ligand plus a PEG5 linker with terminal carboxylic acid ready for conjugation to a target protein ligand

female nude mice bearing HeyA8 tumors in the peritoneal cavity are randomly divided into 4 groups (n=10 per group): 1) vehicle orally twice daily and phosphate-buffered saline intraperitoneally weekly (control)

(2013) Biochem J

Hsp90 antagonist KW-2478 appears to inhibit Hsp90

Raltegravir (MK-0518) r Agonist Androgen synthesis inhibitors in theRaltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection. Product information CAS Number: 518048 05 0 Molecular Weight: 444. 42 Formula: C20H21FN6O5 Synonym: Isentress Related CAS Number: 871038 72 1 (Raltegravir potassium) Chemical Name: N [(4 fluorophenyl)methyl] 5 hydroxy 1 methyl 2 {2 [(5 methyl 1, 3, 4 oxadiazol 2 yl)formamido]propan 2 yl} 6 oxo 1, 6 dihydropyrimidine 4 carboxamide Smiles: